Urinary angiostatin, CXCL4 and VCAM-1 as biomarkers of lupus nephritis
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منابع مشابه
Urinary angiostatin, CXCL4 and VCAM-1 as biomarkers of lupus nephritis
BACKGROUND The aim was to study urinary angiostatin, CXC chemokine ligand 4 (CXCL4) and vascular cell adhesion molecule-1 (VCAM-1) as biomarkers of renal disease in systemic lupus erythematosus (SLE). METHOD Patients who fulfilled ≥ 4 American College of Rheumatology (ACR) criteria for SLE with active renal, active non-renal or inactive disease, and a group of healthy controls were studied. U...
متن کاملUrinary VCAM-1 as a biomarker of lupus nephritis disease activity
Introduction Up to 80% of children with Juvenile Systemic Lupus Erythematosus (JSLE) develop lupus nephritis (LN) (1), with the 5-year renal survival rate varying between 44-94% (2-4). Conventional markers of JSLE disease activity fail to adequately predict impending LN flares (5), with significant renal involvement (class III, IV or V LN) known to occur with low level proteinuria (6). Cross-se...
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Objective(s): Lupus nephritis (LN) is the main cause of mortality and disability in systemic lupus erythematosus (SLE) patients. Therefore, utilizing a reliable and non-invasive method for serial measurements of renal function seems to be necessary. The aim of this study was to evaluate the role of urinary lipocalin-2 as a biomarker of renal involvement in SLE patients. Materi...
متن کاملCan measuring urinary biomarkers improve the management of lupus nephritis?
Although renal biopsy is the most accurate way of assessing renal inflammation in patients with lupus nephritis (LN), the technique is invasive and cannot be performed frequently. Currently used blood and urine biomarkers have limited utility in monitoring the activity of nephritis. In a previous issue of Arthritis Research and Therapy, Singh and colleagues showed that measuring urinary levels ...
متن کاملUrine VCAM-1 as a marker of renal pathology activity index in lupus nephritis
INTRODUCTION Although renal pathology is highly predictive of the disease course in lupus nephritis, it cannot be performed serially because of its invasive nature and associated morbidity. The goal of this study is to investigate whether urinary levels of CXC ligand 16 (CXCL16), monocyte chemotactic protein-1 (MCP-1) or vascular cell adhesion molecule-1 (VCAM-1) in patients with lupus nephriti...
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ژورنال
عنوان ژورنال: Arthritis Research & Therapy
سال: 2018
ISSN: 1478-6362
DOI: 10.1186/s13075-017-1498-3